Chicken Bubble Biscuit Bake Casserole

Save this recipe on:

Comfort food is something I always come back to, especially on busy weeknights or chilly weekends when I want something warm, filling, and incredibly satisfying. That’s where my Chicken Bubble Biscuit Bake Casserole comes in. It’s rich, cheesy, and brimming with savory goodness in every bite. It brings together tender chunks of chicken, golden biscuits, crispy bacon, and a luscious creamy sauce—topped with melted cheese for that irresistible finish.

This dish isn’t just about taste; it’s about simplicity and convenience, too. I love how everything comes together in one pan with very little prep. It’s family-friendly, budget-friendly, and a guaranteed crowd-pleaser at potlucks or gatherings. Plus, the aroma while it’s baking? Absolutely drool-worthy.

Why You’ll Love This Chicken Bubble Biscuit Bake Casserole

• It’s ultra-comforting and cheesy.
• Uses pre-made biscuit dough for easy prep.
• A perfect way to use up leftover or rotisserie chicken.
• Kid-approved and adult-adored.
• Great for dinner, potlucks, or even next-day lunches.

---

What Kind of Biscuits Should I Use?

Refrigerated biscuit dough works best for this recipe—especially the homestyle or buttermilk variety. You can use the larger “Grands”-style biscuits or the smaller ones; just cut them into quarters to help them bake evenly and soak up all that creamy sauce. Avoid flaky layer biscuits as they can separate too much while baking.

---

Options for Substitutions

• Chicken: Swap for shredded turkey or cooked ground beef.
• Cream of Chicken Soup: Use cream of mushroom or cream of celery for a twist.
• Cheese: Mix in Monterey Jack, mozzarella, or pepper jack for added flavor.
• Bacon: Omit for a lighter dish or use turkey bacon.
• Veggies: Add frozen peas, corn, or sautéed mushrooms for more texture and nutrition.

---

Ingredients for this Chicken Bubble Biscuit Bake Casserole

• Cooked Chicken – The hearty base of this casserole. Use shredded rotisserie chicken, leftover roasted chicken, or poached chicken breasts.
• Refrigerated Biscuit Dough – These provide that signature “bubble” texture. Quarter them so they bake evenly and absorb the creamy sauce.
• Cream of Chicken Soup – Adds richness and creaminess to bind everything together. It’s the cozy element of the casserole.
• Sour Cream – Balances the richness with a slight tang and keeps the texture luscious.
• Cheddar Cheese – Melts beautifully and brings that gooey, cheesy pull in every bite. You can also mix in other cheeses for variety.
• Cooked Bacon – Brings smokiness and crunch that complements the creamy interior.
• Garlic Powder – Enhances the overall flavor with subtle depth.
• Salt and Pepper – Essential seasonings to bring out the flavors.
• Fresh Parsley (optional) – A fresh touch for garnish and color.

---

Step 1: Preheat Your Oven

Start by preheating your oven to 350°F (175°C). Lightly grease a 9×13-inch baking dish or a deep casserole dish to prevent sticking.

---

Step 2: Mix the Creamy Base

In a large bowl, combine the cream of chicken soup, sour cream, garlic powder, salt, and pepper. Stir until smooth. This forms the rich, flavorful sauce that holds the casserole together.

---

Step 3: Prepare the Biscuits

Open the can of refrigerated biscuit dough and cut each biscuit into quarters. These smaller pieces will bubble up perfectly in the oven, creating pockets of tender dough inside and crispy tops outside.

---

Step 4: Assemble the Casserole

Add the quartered biscuit pieces, cooked chicken, half of the shredded cheese, and half of the crumbled bacon into the bowl with the sauce. Gently fold everything together until well-coated.

---

Step 5: Transfer to Baking Dish

Pour the entire mixture into your greased baking dish. Spread it evenly, then sprinkle the remaining cheese and bacon on top. This will give the dish a crispy, golden topping.

---

Step 6: Bake Until Golden and Bubbly

Bake uncovered for 30 to 35 minutes, or until the biscuits are cooked through and the top is golden brown. The cheese should be fully melted and slightly crispy on top.

---

Step 7: Garnish and Serve

Remove the casserole from the oven and let it cool for 5 minutes. Garnish with freshly chopped parsley if desired. Serve warm and enjoy that cheesy, biscuit-loaded bite of heaven.

---

How Long to Prepare the Chicken Bubble Biscuit Bake Casserole

Prep Time: Most of the work here is in gathering and mixing the ingredients. If you’re using rotisserie or pre-cooked chicken, prep takes about 10 to 15 minutes. Cutting the biscuits, shredding cheese, and assembling the casserole are quick and easy.

Cooking Time: The casserole bakes for 30 to 35 minutes at 350°F. You’ll want the biscuits to puff up and turn golden on top while the inside becomes bubbly and creamy. Let it cool for 5 minutes before serving.

---

Tips for Perfect Chicken Bubble Biscuit Bake Casserole

• Cut biscuits evenly to ensure uniform baking.
• Mix ingredients gently to avoid squishing the biscuit dough.
• Add cheese on top in the last 10 minutes if you want it extra gooey.
• Use a deep baking dish to prevent bubbling over.
• Let the casserole rest before cutting to help it firm up slightly.

---

Watch Out for These Mistakes While Cooking

• Undercooking the biscuits: Always check the center biscuits to make sure they’re fully baked and not doughy.
• Using too much liquid: Extra sour cream or soup might make the casserole soggy.
• Overcrowding the pan: Leave some space for the biscuits to expand and bubble.
• Forgetting seasoning: Taste the sauce before mixing everything to adjust salt and pepper.
• Baking covered: This can trap too much moisture and leave the top soft instead of golden and crisp.

---

What to Serve With Chicken Bubble Biscuit Bake Casserole?

1. Simple Garden Salad

A fresh contrast to the creamy casserole, especially with a vinaigrette dressing.

2. Roasted Green Beans

Crisp, oven-roasted green beans add a light and nutritious side.

3. Garlic Butter Corn on the Cob

The sweet, buttery corn pairs perfectly with the savory richness.

4. Pickled Vegetables

Tangy pickles or a quick cucumber salad cut through the creaminess.

5. Applesauce or Cranberry Sauce

Adds a sweet contrast and balances the flavors.

---

Storage Instructions

Refrigerator: Store leftovers in an airtight container in the refrigerator for up to 3 days. Reheat in the oven or microwave until warm all the way through. Add a bit of extra cheese on top before reheating for a fresh-from-the-oven taste.

Freezer: You can freeze the baked casserole for up to 2 months. Wrap tightly in foil and store in a freezer-safe bag or container. Thaw overnight in the fridge and reheat in the oven at 350°F until heated through.

---

Estimated Nutrition

Serving Size: 1 portion (based on 6 servings)

• Calories: ~450
• Protein: 22g
• Carbohydrates: 30g
• Fat: 26g
• Saturated Fat: 12g
• Fiber: 1g
• Sugar: 3g
• Sodium: 870mg
• Cholesterol: 70mg

---

Frequently Asked Questions

How do I know when the casserole is done baking?

Check the top for a golden brown color and insert a knife or toothpick into the center to ensure the biscuits are cooked through.

Can I make this casserole ahead of time?

Yes! Assemble everything in the baking dish, cover tightly, and refrigerate up to 24 hours before baking.

What type of chicken works best?

Rotisserie chicken, leftover baked chicken, or any cooked, shredded chicken will work. Just avoid anything heavily seasoned.

Can I use homemade biscuit dough?

Definitely! Just make sure to roll it out and cut into small, even chunks so it bakes evenly.

How do I make it spicier?

Add diced jalapeños, pepper jack cheese, or a dash of hot sauce to the mixture.

---

Conclusion

Chicken Bubble Biscuit Bake Casserole is the definition of cozy, hearty comfort food. With minimal prep and loads of flavor, it’s a go-to recipe for feeding a hungry family or making an impression at a potluck. Creamy, cheesy, and full of texture—this dish never disappoints. Once you try it, it’ll earn a permanent spot in your dinner rotation.

---

Print

Save this recipe on: